The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

This paper is a study about Philadelphia’s comprehensive user engagement sites (CUESs) as the authors address and examine issues related to the upcoming implementation of a CUES while seeking solutions for its disputed questions and plans. Beginning with the federal drug schedules, the authors visit some of the medical and public health issues vis-à-vis safe injection facilities (SIFs). Insite, a successful Canadian SIF, has been thoroughly researched as it represents a paradigm for which a Philadelphia CUES can expand upon. Also, (...) the existing criticisms against SIFs are revisited while critically unpackaged and responded to in favor of the establishment. In the main section, the authors propose the layout and services of the upcoming CUES, much of which would be in congruent to Vancouver’s Insite. On the other hand, the CUES would be distinct from Insite, as the authors emphasize, in that it will offer an information center run by individuals in recovery and place additional emphasis on early education for young healthcare professionals by providing them a platform to work at the site. The paper will also briefly investigate the implementation of a CUES site under an ethical scope of the Harm Reduction Theory. Lastly, the authors recommend some strategic plans that the Philadelphia City government may consider employing at this crucial stage. (shrink)

RESUMO A alimentação é o fator que mais onera um sistema de produção animal. Assim, a utilização de diferentes estratégias de alimentação dos animais ainda é o grande desafio da nutrição animal, principalmente, levando em consideração as exigências nutricionais de diferentes categorias de ruminantes, em especial bovinos em regiões tropicais, haja vista que a sazonalidade na produção de forragens afeta diretamente a produção bovina, promovendo inadequação no atendimento das exigências nutricionais dos animais principalmente em minerais e vitaminas. Uma alimentação que (...) não atenda as exigências nutricionais dos ruminantes gera prejuízos no sistema de produção, além de, em casos mais graves, ocasionar a perda do animal. Estudos que abordam o efeito e a importância de vitaminas e minerais na nutrição bovina são escassos e necessários. Recentemente a National Research Council (NRC) apresentou novos registros das exigências nutricionais das vitaminas e minerais. Essas alterações proporcionam um impacto econômico significativo em relação à nutrição animal. Nesse sentido, objetivou-se com esta revisão trazer informações acerca de vitaminas e minerais na nutrição de bovinos em pastejo. -/- Palavras-chave: Alimentação animal; forragem; pastagem; requerimentos nutricionais; ruminantes; vitaminas lipossolúveis (Source: AGROVOC). -/- ABSTRACT Animal feed is the factor that most burdens a production system. Thus, the use of different animal feeding strategies is still the great challenge of animal nutrition, taking into account the nutritional requirements of different categories of ruminants, especially cattle in tropical regions, given that seasonality in forage production directly affects cattle production, promoting inadequacy in meeting the nutritional requirements of animals, mainly in minerals and vitamins. A diet that does not meet the nutritional requirements of ruminants generates losses in the production system, in addition to, in more serious cases, causing the loss of the animal. Studies that address the effect and importance of vitamins and minerals in bovine nutrition are scarce and necessary. Recently the National Research Council (NRC) presented new records of the nutritional requirements of vitamins and minerals. These changes provide a significant economic impact on animal nutrition. In this sense, the objective of this review was to bring information about vitamins and minerals in the nutrition of grazing cattle. -/- Keywords: Animal feeding; fat soluble vitamins; forage; nutritional requirements; pasture feeding; ruminants (Source: AGROVOC). -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- 1. Cavalcanti CPL, Silva e Macedo TJ, Gois GC, Menezes VG, Monte APO, Silva AD, Silva DJM, Silva EO, Araújo GGL, Rodrigues RTS, Wischral A, Matos MHT, Queiroz MAA. 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Paul SH, Usman AA, Gana IN, Manase A, Adeniyi OD, Olutoye MA. Comparative study of mineral and nutritional composition of a multifunctional flora composite formulated from seven medicinal plants and their applications to human health. Eng Techn Open Access J. 2018; 1:137-150. 30. Zhou J, Zhang J, Xue B, Yue S, Yang C, Xue B. Effects of premating calcium and phosphorus supplementation on reproduction efficiency of grazing yak heifers. Anim. 2021; 11:1-9. 31. Harder H, Khol-Parisini A, Metzler-Zebeli BU, Klevenhusen F, Zebeli Q. Treatment of grain with organic acids at 2 different dietary phosphorus levels modulates ruminal microbial community structure and fermentation patterns in vitro. J Dairy Sci. 2015; 98:8107–8120. 32. Jain RK, Mudgal V. Phosphorus deficiency influences rumen microbial activity: Review. Int J Zoo Anim Biol. 2021; 4:1-9. 33. Barreto JC, Branco AF, Santos GT, Magalhães VJA, Coneglian SMC, Teixeira S. Avaliação dos efeitos de fontes de fósforo na dieta sobre parâmetros do meio ruminal e eficiência de síntese microbiana, digestibilidade dos nutrientes e fósforo plasmático em bovinos. Rev Bras Zootec. 2009; 38:760-769. 34. Yamada S, Inaba M. Potassium metabolism and management in patients with CKD. Nutr. 2021; 13:1-19. 35. Martinsen TC, Fossmark R, Waldum HL. The phylogeny and biological function of gastric juice—Microbiological consequences of removing gastric acid. Int J Mol Sci. 2019; 20:1-22. 36. González FHD, Silva SC. Minerais e vitaminas no metabolismo animal. 1st ed. Porto Alegre: Universidade Federal do Rio Grande do Sul; 2019. 37. Melo RR, Gonçalves SLS, Baccarin FJB, Vasconcelos WA, Miranda SC. Influência de altas dosagens de cloreto de potássio no desenvolvimento de espécies em cultivo hidropônico. Pubvet. 2020; 14:1-9. 38. Araújo WAG, Rostagno HS, Albino LFT, Carvalho TA, Ribeiro Neto AC. Potássio na nutrição animal. Rev Eletr Nutr. 2010; 7:1280-1291. 39. NRC. National Research Council. Nutrient requeriments of dairy cattle. 8th ed. Washinton, DC.: The National Academy Press; 2021. 40. Palomares RA. Trace Minerals Supplementation with Great Impact on Beef Cattle Immunity and Health. Anim. 2022; 12:e2839. 41. Tariq M, Abbas G, Ahmad S, Mustafa R, Sultan H, Abdullah M, Hussain I, Arshad M, Cheema UB, Hassan SU. Effect of supplementation of minerals on the productive and reproductive performance of lactating cattle and buffalo. Pakistan J Sci. 2022; 74:e425. 42. Pagno KCA Barbosa JD, Salvarani FM, Bomjardim HA, Faial KCF, Souza RS, Gava A, Perotta JH, Barros Filho IR. Micromineral concentrations (copper, cobalt, iron, molybdenum and zinc) in the liver of dairy cows from Campos Gerais Region, Paraná state, Brazil. Pesq Vet Bras. 2023; 43:e07137. 43. Jeong H, Vacanti NM. Systemic vitamin intake impacting tissue proteomes. Nut Met. 2020; 17:1-16. 44. Spears JW, Weiss WP. Invited Review: Mineral and vitamin nutrition in ruminants. Appl Anim Sci. 2014; 30:180-191. 45. Erickson PS, Kalscheur KF. Nutrition and feeding of dairy cattle. Chapter 9. (pp. 157-180). In: Bazer FW, Lamb GC, Wu G, editors. Animal Agriculture. Sustainability, Challenges and Innovations. 1st ed. Elsevier Inc.: Academic Press; 2020. 46. Kareem MM, Jabir MS. Vitamins. Chapter 3. In: Imran M, Imran A, editors. Malnutrition. 1st ed. London, UK.: IntechOpen; 2020. 47. Akram M, Munir N, Daniyal M, Egbuna C, Găman MA, Onyekere PF, et al. Vitamins and minerals: Types, sources and their functions. Chapter 9. (pp 149–172). In: Egbuna C, Tupas GD, editors. Functional foods and nutraceuticals. Switzerland, AG.: Springer, Cham; 2020. 48. Marino CT, Medeiros SR. Minerais e vitaminas na nutrição de bovinos de corte. Chapter 6. (pp. 79-93). In. Medeiros SR, Gomes RC, Bungenstab DJ, editors. Nutrição de bovinos de corte: fundamentos e aplicações. Brasília, DF: Embrapa; 2015. 49. Hodnik JJ, Ježek J, Starič J. A review of vitamin D and its importance to the health of dairy cattle. J Dairy Res. 2020; 87:84–87. 50. Alves EM, Pedreira MS, Santana CA, Silva FF. Nutrição vitamínica de vacas leiteiras. Pubvet. 2008; 2:1-17. 51. Jiang Q, Lin L, Xie F, Jin W, Zhu W, Wang M, et al. Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants. Microb. 2022; 10:1-16. 52. Magan JB, O’Callaghan TF, Zheng J, Zhang L, Mandal R, Hennessy D, et al. Effect of diet on the vitamin B profile of bovine milk-based protein ingredients. Foods. 2020; 9:1-17. 53. Pinedo LA, Berenchtein B, Selem ASMA. Estudo dos processos bioquímicos da fermentação, degradação e absorção de nutrientes dos alimentos em ruminantes. Pubvet. 2008; 2:1-10. 54. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Avaliação de Suplemento Mineral Para Caprinos. Instrução Técnica Para o Produtor Rural de Pernambuco, v. 3, n. 1, p. 1-4, 2023. 55. DA SILVA, Emanuel Isaque Cordeiro. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. Emanuel Isaque Cordeiro da Silva, 2021. 56. DA SILVA, Emanuel Isaque Cordeiro. Suplementação e formulação de sal mineral e mistura múltipla para bovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. (shrink)

Most discussions of racial fetish center on the question of whether it is caused by negative racial stereotypes. In this paper I adopt a different strategy, one that begins with the experiences of those targeted by racial fetish rather than those who possess it; that is, I shift focus away from the origins of racial fetishes to their effects as a social phenomenon in a racially stratified world. I examine the case of preferences for Asian women, also known as ‘yellow (...) fever’, to argue against the claim that racial fetishes are unobjectionable if they are merely based on personal or aesthetic preference rather than racial stereotypes. I contend that even if this were so, yellow fever would still be morally objectionable because of the disproportionate psychological burdens it places on Asian and Asian-American women, along with the role it plays in a pernicious system of racial social meanings. (shrink)

Predictable polarization is everywhere: we can often predict how people’s opinions, including our own, will shift over time. Extant theories either neglect the fact that we can predict our own polarization, or explain it through irrational mechanisms. They needn’t. Empirical studies suggest that polarization is predictable when evidence is ambiguous, that is, when the rational response is not obvious. I show how Bayesians should model such ambiguity and then prove that—assuming rational updates are those which obey the value of evidence—ambiguity (...) is necessary and sufficient for the rationality of predictable polarization. The main theoretical result is that there can be a series of such updates, each of which is individually expected to make you more accurate, but which together will predictably polarize you. Polarization results from asymmetric increases in accuracy. This mechanism is not only theoretically possible, but empirically plausible. I argue that cognitive search—searching a cognitively accessible space for a particular item—often yields asymmetrically ambiguous evidence, I present an experiment supporting its polarizing effects, and I use simulations to show how it can explain two of the core causes of polarization: confirmation bias and the group polarization effect. (shrink)

The Lockean Thesis says that you must believe p iff you’re sufficiently confident of it. On some versions, the 'must' asserts a metaphysical connection; on others, it asserts a normative one. On some versions, 'sufficiently confident' refers to a fixed threshold of credence; on others, it varies with proposition and context. Claim: the Lockean Thesis follows from epistemic utility theory—the view that rational requirements are constrained by the norm to promote accuracy. Different versions of this theory generate different versions of (...) Lockeanism; moreover, a plausible version of epistemic utility theory meshes with natural language considerations, yielding a new Lockean picture that helps to model and explain the role of beliefs in inquiry and conversation. Your beliefs are your best guesses in response to the epistemic priorities of your context. Upshot: we have a new approach to the epistemology and semantics of belief. And it has teeth. It implies that the role of beliefs is fundamentally different than many have thought, and in fact supports a metaphysical reduction of belief to credence. (shrink)

Kevin Lynch's books are the classic underpinnings of modern urban planning and design, yet they are only a part of his rich legacy of ideas about human purposes and values in built form. City Sense and City Design brings together Lynch's remaining work, including professional design and planning projects that show how he translated many of his ideas and theories into practice. An invaluable sourcebook of design knowledge, City Sense and City Design completes the record of one of the (...) foremost environmental design theorists of our time and leads to a deeper understanding of his distinctively humanistic philosophy. The editors, both former students of Lynch, provide a cogent summary of his career and of the role he played in shaping and transforming the American urban design profession during the 1950s, the 1960s, and the 1970s. Each of the seven thematic groupings of writings and projects that follow begins with a short introduction explaining their content and their background. The essays in part I focus on the premises of Lynch's work: his novel reading of large-scale built environments and the notion that the design of an urban landscape should be as meaningful and intimate as the natural landscape. In part II, excerpts from Lynch's travel journals reveal his early ideas on how people perceive and interpret their surroundings—ideas that culminated in his seminal work, The Image of the City. This part of the book also presents Lynch's experiments with children and his assessment of environmental-perception research. The examples of both small-scale and large-scale analysis of visual form in part III are followed by three parts on city design. These include Lynch's more theoretical works on complex planning decisions involving both functional (spatial and structural organization) and normative (how the city works in human terms) approaches, articles discussing the principles that guided Lynch's teaching and practice of city design, and descriptions of Lynch's own projects in the Boston area and elsewhere. The book concludes with essays written late in Lynch's career, fantasy pieces describing utopias and offering new design freedoms and scenarios warning of horrifying "cacotopias.". (shrink)

‘What is characteristic of every mental activity’, according to Brentano, is ‘the reference to something as an object. In this respect every mental activity seems to be something relational.’ But what sort of a relation, if any, is our cognitive access to the world? This question – which we shall call Brentano’s question – throws a new light on many of the traditional problems of epistemology. The paper defends a view of perceptual acts as real relations of a subject to (...) an object. To make this view coherent, a theory of different types of relations is developed, resting on ideas on formal ontology put forward by Husserl in his Logical Investigations and on the theory of relations sketched in Smith's "Acta cum fundamentis in re". The theory is applied to the notion of a Cambridge change, which proves to have an unforeseen relevance to our understanding of perception. (shrink)

Philosophers and linguists currently lack the means to reliably identify evaluative concepts and measure their evaluative intensity. Using a corpus-based approach, we present a new method to distinguish evaluatively thick and thin adjectives like ‘courageous’ and ‘awful’ from descriptive adjectives like ‘narrow,’ and from value-associated adjectives like ‘sunny.’ Our study suggests that the modifiers ‘truly’ and ‘really’ frequently highlight the evaluative dimension of thick and thin adjectives, allowing for them to be uniquely classified. Based on these results, we believe our (...) operationalization may pave the way for a more quantitative approach to the study of thick and thin concepts. (shrink)

abstract: Richard T. Greener was the first Black graduate of Harvard College in 1870, and he served briefly as a professor of philosophy at the University of South Carolina from 1873 to 1877. Historians and biographers have uncovered many of the facts of his unusual life, but to date his philosophy has remained unappreciated. This essay reconstructs his philosophy from published and archival sources, evaluating it in relationship to the work of his better-known mentor, Frederick Douglass. I argue that Greener’s (...) account of Reconstruction politics, especially his arguments on land redistribution, race, and Black intellectual history, possess notable advantages over Douglass’s views. Of particular importance is that he defended a more robust republican state than did his hero, while rejecting the originalism and constitutionalism that characterize Douglass’s liberalism. (shrink)

A realist theory of truth for a class of sentences holds that there are entities in virtue of which these sentences are true or false. We call such entities ‘truthmakers’ and contend that those for a wide range of sentences about the real world are moments (dependent particulars). Since moments are unfamiliar, we provide a definition and a brief philosophical history, anchoring them in our ontology by showing that they are objects of perception. The core of our theory is the (...) account of truthmaking for atomic sentences, in which we expose a pervasive ‘dogma of logical form’, which says that atomic sentences cannot have more than one truthmaker. In contrast to this, we uphold the mutual independence of logical and ontological complexity, and the authors outline formal principles of truthmaking taking account of both kinds of complexity. (shrink)

The categorical imperative inherent in Kant’s ethics has had indubitable historical influence on societies worldwide whether in the form of laws, democracy or public deliberation. The Toronto Van Attack of 2018 and its subsequent legal trial is a case example that shows how the categorical imperative can be applied to assist in understanding the reasoning for the case’s guilty verdict. This paper will convey the applicability of the categorical imperative for examining criminal case studies by closing the gap between ethical (...) theory and practice. Such closure will be shown to assist in understanding why a perpetrator of a crime can be found guilty of following a hypothetical imperative to base their actions. The rationale for the verdict in this case will be shown to be based on the perpetrator’s responsibility in the form of maintaining autonomy despite having an autism diagnosis. The perpetrator will be shown to have acted on an irrational will and yet was treated in the legal sense as a rational individual. Such rationality was maintained despite complications with their autonomy in the form of relativism and ethical solipsism. (shrink)

Many moral error theorists reject moral realism on the grounds that moral realism implies the existence of categorical normativity, yet categorical normativity does not exist. Call this the Metaphysical Argument. In response, some moral realists have emphasized a parity between moral normativity and epistemic normativity. They argue that if one kind of normativity is rejected, then both must be rejected. Therefore, one cannot be a moral error theorist without also being an epistemic error theorist. Call this the Parity Argument. In (...) this paper, we address three possible responses to the Parity Argument from moral error theorists: (1) accept the parity but still reject epistemic error theory, (2) reject the parity, (3) accept the parity and defend epistemic error theory. We argue that there are problems with each of these responses, so the Parity Argument stands as a strong counterargument to the Metaphysical Argument. We conclude by drawing some lessons for any future challenges to the Parity Argument. (shrink)

There are many things—call them ‘experts’—that you should defer to in forming your opinions. The trouble is, many experts are modest: they’re less than certain that they are worthy of deference. When this happens, the standard theories of deference break down: the most popular (“Reflection”-style) principles collapse to inconsistency, while their most popular (“New-Reflection”-style) variants allow you to defer to someone while regarding them as an anti-expert. We propose a middle way: deferring to someone involves preferring to make any decision (...) using their opinions instead of your own. In a slogan, deferring opinions is deferring decisions. Generalizing the proposal of Dorst (2020a), we first formulate a new principle that shows exactly how your opinions must relate to an expert’s for this to be so. We then build off the results of Levinstein (2019) and Campbell-Moore (2020) to show that this principle is also equivalent to the constraint that you must always expect the expert’s estimates to be more accurate than your own. Finally, we characterize the conditions an expert’s opinions must meet to be worthy of deference in this sense, showing how they sit naturally between the too-strong constraints of Reflection and the too-weak constraints of New Reflection. (shrink)

KK is the thesis that if you can know p, you can know that you can know p. Though it’s unpopular, a flurry of considerations has recently emerged in its favour. Here we add fuel to the fire: standard resources allow us to show that any failure of KK will lead to the knowability and assertability of abominable indicative conditionals of the form ‘If I don’t know it, p’. Such conditionals are manifestly not assertable—a fact that KK defenders can easily (...) explain. I survey a variety of KK-denying responses and find them wanting. Those who object to the knowability of such conditionals must either deny the possibility of harmony between knowledge and belief, or deny well-supported connections between conditional and unconditional attitudes. Meanwhile, those who grant knowability owe us an explanation of such conditionals’ unassertability—yet no successful explanations are on offer. Upshot: we have new evidence for KK. (shrink)

Statistics play a critical role in biological and clinical research. However, most reports of scientific results in the published literature make it difficult for the reader to reproduce the statistical analyses performed in achieving those results because they provide inadequate documentation of the statistical tests and algorithms applied. The Ontology of Biological and Clinical Statistics (OBCS) is put forward here as a step towards solving this problem. Terms in OBCS, including ‘data collection’, ‘data transformation in statistics’, ‘data visualization’, ‘statistical data (...) analysis’, and ‘drawing a conclusion based on data’, cover the major types of statistical processes used in basic biological research and clinical outcome studies. OBCS is aligned with the Basic Formal Ontology (BFO) and extends the Ontology of Biomedical Investigations (OBI), an OBO (Open Biological and Biomedical Ontologies) Foundry ontology supported by over 20 research communities. We discuss two examples illustrating how the ontology is being applied. In the first (biological) use case, we describe how OBCS was applied to represent the high throughput microarray data analysis of immunological transcriptional profiles in human subjects vaccinated with an influenza vaccine. In the second (clinical outcomes) use case, we applied OBCS to represent the processing of electronic health care data to determine the associations between hospital staffing levels and patient mortality. Our case studies were designed to show how OBCS can be used for the consistent representation of statistical analysis pipelines under two different research paradigms. By representing statistics-related terms and their relations in a rigorous fashion, OBCS facilitates standard data analysis and integration, and supports reproducible biological and clinical research. (shrink)

This paper develops a problem for conciliationism that is structurally similar to the self-undermining problem but which is immune to most of the solutions offered against it. A popular objection to conciliationism is that it undermines itself. Given the current disagreement among philosophers about conciliationism, conciliationism seems to require rejecting conciliationism. Adam Elga (2010) has influentially argued that this shows that conciliationism is an incoherent method. By recommending its own rejection, conciliationism recommends multiple, incompatible responses to the same body of (...) experience. Many have offered solutions to this problem, including Elga himself. However, there is another undermining problem. When a peer disagrees about their own peerhood, conciliationism can require the rejection of the peer’s peerhood. The result is that conciliationism recommends two incompatible responses to the same body of experience in a way that parallels the original self-undermining problem. But since many, if not all, of the proposed solutions to the original undermining problem depend on distinctive characteristics of conciliationism undermining itself, they cannot apply to a peer undermining themself. I illustrate this by dividing the solutions that have been offered against the self-undermining problem into two categories: self-exempting solutions and non-exempting solutions. I then show how the proposed solutions under each type do not extend to the peer-undermining problem. If that is right, then conciliationism is faced with a more difficult undermining problem than has been so far acknowledged. (shrink)

Through a series of empirical studies involving native speakers of English, German, and Chinese, this paper reveals that the predicate “true” is inherently ambiguous in the empirical domain. Truth statements such as “It is true that Tom is at the party” seem to be ambivalent between two readings. On the first reading, the statement means “Reality is such that Tom is at the party.” On the second reading, the statement means “According to what X believes, Tom is at the party.” (...) While there appear to exist some cross-cultural differences in the interpretation of the statements, the overall findings robustly indicate that “true” has multiple meanings in the realm of empirical matters. (shrink)

Of the dozens of purported solutions to the liar paradox published in the past fifty years, the vast majority are "traditional" in the sense that they reject one of the premises or inference rules that are used to derive the paradoxical conclusion. Over the years, however, several philosophers have developed an alternative to the traditional approaches; according to them, our very competence with the concept of truth leads us to accept that the reasoning used to derive the paradox is sound. (...) That is, our conceptual competence leads us into inconsistency. I call this alternative the inconsistency approach to the liar. Although this approach has many positive features, I argue that several of the well-developed versions of it that have appeared recently are unacceptable. In particular, they do not recognize that if truth is an inconsistent concept, then we should replace it with new concepts that do the work of truth without giving rise to paradoxes. I outline an inconsistency approach to the liar paradox that satisfies this condition. (shrink)

Prominent memeticists like Daniel Dennett and Susan Blackmore have made claims far more radical than those included in Dawkins’ original proposal, which provoked increasingly heated debates and arguments over the theoretical significance as well as limits or flaws of the entire memetic enterprise. In this paper, I examine closely some of the critical points taken by Kate Distin in her penetrating engagement with those radical claims, which include such ideas as the thought that we are meme machines as much as (...) gene machines, the thesis that there is no conscious self inside those machines, and the claim that a complex interplay of replicators and environment is all there is to life (Blackmore 1999: 241). It is hoped that a viable thesis concerning a deep-seated normativity emerges from my discussion. (shrink)

Statistics play a critical role in biological and clinical research. To promote logically consistent representation and classification of statistical entities, we have developed the Ontology of Biological and Clinical Statistics (OBCS). OBCS extends the Ontology of Biomedical Investigations (OBI), an OBO Foundry ontology supported by some 20 communities. Currently, OBCS contains 686 terms, including 381 classes imported from OBI and 147 classes specific to OBCS. The goal of this paper is to present OBCS for community critique and to describe a (...) number of use cases designed to illustrate its potential applications. The OBCS project and source code are available at http://obcs.googlecode.com. (shrink)

This article presents a robust defense of the concept of “datafied enhancement” as a subset of human enhancement. Firstly, the author notes that the widespread development of ICT and AI technologies has made it possible to collect and analyze human biometric data, thus integrating data into the concept of embodiment. Secondly, the author explores the cultural and intellectual history of datafied enhancement, highlighting the significant role data has played in human evolution. Thirdly, the author examines the functional classifications of datafied (...) enhancement, arguing that conversational, wearable, ingestible, and embeddable technological devices can enhance individuals’ physical, cognitive, emotional, and moral capacities by collecting body data. Fourthly, the author underscores the importance of distinguishing datafied enhancement from dataism to avoid misconceptions. Finally, the author addresses potential ethical issues, such as data exclusivity, the uncontrollable data self, and privacy invasion. By acknowledging these risks, datafied enhancement can be guided to become a technology that respects human dignity and promotes the common good. (shrink)

Assume that it is your evidence that determines what opinions you should have. I argue that since you should take peer disagreement seriously, evidence must have two features. (1) It must sometimes warrant being modest: uncertain what your evidence warrants, and (thus) uncertain whether you’re rational. (2) But it must always warrant being guided: disposed to treat your evidence as a guide. Surprisingly, it is very difficult to vindicate both (1) and (2). But diagnosing why this is so leads to (...) a proposal—Trust—that is weak enough to allow modesty but strong enough to yield many guiding features. In fact, I claim that Trust is the Goldilocks principle—for it is necessary and sufficient to vindicate the claim that you should always prefer to use free evidence. Upshot: Trust lays the foundations for a theory of disagreement and, more generally, an epistemology that permits self-doubt—a modest epistemology. (shrink)

This paper is about guessing: how people respond to a question when they aren’t certain of the answer. Guesses show surprising and systematic patterns that the most obvious theories don’t explain. We argue that these patterns reveal that people aim to optimize a tradeoff between accuracy and informativity when forming their guess. After spelling out our theory, we use it to argue that guessing plays a central role in our cognitive lives. In particular, our account of guessing yields new theories (...) of belief, assertion, and the conjunction fallacy—the psychological finding that people sometimes rank a conjunction as more probable than one of its conjuncts. More generally, we suggest that guessing helps explain how boundedly rational agents like us navigate a complex, uncertain world. (shrink)

The Twin Earth thought experiment invites us to consider a liquid that has all of the superficial properties associated with water (clear, potable, etc.) but has entirely different deeper causal properties (composed of “XYZ” rather than of H2O). Although this thought experiment was originally introduced to illuminate questions in the theory of reference, it has also played a crucial role in empirically informed debates within the philosophy of psychology about people’s ordinary natural kind concepts. Those debates have sought to accommodate (...) an apparent fact about ordinary people’s judgments: Intuitively, the Twin Earth liquid is not water. We present results from four experiments showing that people do not, in fact, have this intuition. Instead, people tend to have the intuition that there is a sense in which the liquid is not water but also a sense in which it is water. We explore the implications of this finding for debates about theories of natural kind concepts, arguing that it supports views positing two distinct criteria for membership in natural kind categories – one based on deeper causal properties, the other based on superficial, observable properties. (shrink)

Generic statements (‘Tigers have stripes’) are pervasive and developmentally early-emerging modes of generalization with a distinctive linguistic profile. Previous experimental work suggests that generics display a unique asymmetry between the prevalence levels required to accept them and the prevalence levels typically implied by their use. This asymmetry effect is thought to have serious social consequences: if speakers use socially problematic generics based on prevalence levels that are systematically lower than what is typically inferred by their recipients, then using generics will (...) likely exacerbate social stereotypes and biases. This paper presents evidence against the popular hypothesis that this asymmetry effect is unique to generics. Correcting for various shortcomings of previous studies, we found a generalized asymmetry effect across generics and various kinds of explicitly quantified statements (‘most’, ‘some’, ‘typically’, ‘usually’). In addition, to better understand the conditions under which generalized asymmetry effects may exacerbate biases, we examine whether speakers choose generalizing sentences based simply on their acceptance conditions, or are systematically sensitive to the implications likely drawn by their typical recipients. In support of the latter view, we found that, in neutral or cooperative scenarios, speakers reliably choose generalizing sentences whose implied prevalence levels closely match the actual ones. In non-cooperative scenarios, speakers exploit asymmetry effects to further their own goals by choosing generalizing sentences that are strictly true but likely to mislead their recipients. These results refine our understanding of the source of asymmetry effects and the conditions under which they may introduce biased beliefs into social networks. (shrink)

“Experimental jurisprudence” draws on empirical data to inform questions typically associated with jurisprudence or legal theory. Scholars in this flourishing movement conduct empirical studies about a variety of legal language and concepts. Despite the movement’s growth, its justification is still opaque. Jurisprudence is the study of deep and longstanding theoretical questions about law’s nature, but “experimental jurisprudence,” it might seem, simply surveys laypeople. This Article elaborates and defends experimental jurisprudence. Experimental jurisprudence, appropriately understood, is not only consistent with traditional jurisprudence; (...) it is an essential branch of it. (shrink)

This paper primarily investigates the following questions: The first question：What is the basic structure of consciousness? I proposed that objects moving at the speed of light form the fundamental structure of consciousness. The second question:How is the unified field of the conscious self formed? The study suggests that countless particles moving at the speed of light, through quantum entanglement, form the unified field of each individual's consciousness. Each individual's unified field consists of countless particles originating from a source, which can (...) be referred to as the "soul quantum." The third question:What is the mechanism underlying the formation of different forms of imagery (images, sounds, and bodily sensations)? The study posits that when the wave-particle duality of quantum mechanics collapses, it results in different forms of imagery. (shrink)

The standard view in philosophy treats pains as phenomenally conscious mental states. This view has a number of corollaries, including that it is generally taken to rule out the existence of unfelt pains. The primary argument in support of the standard view is that it supposedly corresponds with the commonsense conception of pain. In this paper, we challenge this doctrine about the commonsense conception of pain, and with it the support offered for the standard view, by presenting the results of (...) a series of new empirical studies that indicate that lay people not only tend to believe that unfelt pains are possible, but actually, quite common. (shrink)

You have higher-order uncertainty iff you are uncertain of what opinions you should have. I defend three claims about it. First, the higher-order evidence debate can be helpfully reframed in terms of higher-order uncertainty. The central question becomes how your first- and higher-order opinions should relate—a precise question that can be embedded within a general, tractable framework. Second, this question is nontrivial. Rational higher-order uncertainty is pervasive, and lies at the foundations of the epistemology of disagreement. Third, the answer is (...) not obvious. The Enkratic Intuition---that your first-order opinions must “line up” with your higher-order opinions---is incorrect; epistemic akrasia can be rational. If all this is right, then it leaves us without answers---but with a clear picture of the question, and a fruitful strategy for pursuing it. (shrink)

Do people tend to be overconfident? Many think so. They’ve run studies on whether people are calibrated: whether their average confidence in their opinions matches the proportion of those opinions that are true. Under certain conditions, people are systematically ‘over-calibrated’—for example, of the opinions they’re 80% confident in, only 60% are true. From this empirical over-calibration, it’s inferred that people are irrationally overconfident. My question: When and why is this inference warranted? Answering it requires articulating a general connection between being (...) rational and being right—something extant studies have not done. I show how to do so using the notion of deference. This provides a theoretical foundation for calibration research, but also reveals a flaw: the connection between being rational and being right is much weaker than is standardly assumed, since rational people can often be expected to be miscalibrated. Thus we can’t test whether people are overconfident by simply testing whether they are over-calibrated; instead, we must try to predict the rational deviations from calibration, and then compare those predictions to people’s performance. I show how this can be done—and that doing so complicates the interpretation of robust empirical effects. (shrink)

The gambler’s fallacy is the tendency to expect random processes to switch more often than they actually do—for example, to think that after a string of tails, a heads is more likely. It’s often taken to be evidence for irrationality. It isn’t. Rather, it’s to be expected from a group of Bayesians who begin with causal uncertainty, and then observe unbiased data from an (in fact) statistically independent process. Although they converge toward the truth, they do so in an asymmetric (...) way—ruling out “streaky” hypotheses more quickly than “switchy” ones. As a result, the majority (and the average) exhibit the gambler’s fallacy. If they have limited memory, this tendency persists even with arbitrarily-large amounts of data. Indeed, such Bayesians exhibit a variety of the empirical trends found in studies of the gambler’s fallacy: they expect switches after short streaks but continuations after long ones; these nonlinear expectations vary with their familiarity with the causal system; their predictions depend on the sequence they’ve just seen; they produce sequences that are too switchy; and they exhibit greater rates of gambler’s reasoning when forming binary predictions than when forming probability estimates. In short: what’s been thought to be evidence for irrationality may instead be rational responses to limited data and memory. (shrink)

Generic statements (‘Tigers have stripes’) are pervasive and early-emerging modes of generalization with a distinctive linguistic profile. Previous experimental work found that generics display a unique asymmetry between their acceptance conditions and the implications that are typically drawn from them. This paper presents evidence against the hypothesis that only generics display an asymmetry. Correcting for limitations of previous designs, we found a generalized asymmetry effect across generics, various kinds of explicitly quantified statements (‘most’, ‘some’, ‘typically’, ‘usually’), and variations in types (...) of predicated properties (striking vs. neutral). We discuss implications of these results for our understanding of the source of asymmetry effects and whether and in which ways these effects might introduce biased beliefs into social networks. (shrink)

Causal selection is the cognitive process through which one or more elements in a complex causal structure are singled out as actual causes of a certain effect. In this paper, we report on an experiment in which we investigated the role of moral and temporal factors in causal selection. Our results are as follows. First, when presented with a temporal chain in which two human agents perform the same action one after the other, subjects tend to judge the later agent (...) to be the actual cause. Second, the impact of temporal location on causal selection is almost canceled out if the later agent did not violate a norm while the former did. We argue that this is due to the impact that judgments of norm violation have on causal selection—even if the violated norm has nothing to do with the obtaining effect. Third, moral judgments about the effect influence causal selection even in the case in which agents could not have foreseen the effect and did not intend to bring it about. We discuss our findings in connection to recent theories of the role of moral judgment in causal reasoning, on the one hand, and to probabilistic models of temporal location, on the other. (shrink)

Abstract: From familiar concepts like TALL and TABLE to exotic ones like GRAVITY and GENOCIDE, they guide our lives and are the basis for how we represent the world. However, there is good reason to think that many of our most cherished concepts, like TRUTH, FREEDOM, KNOWLEDGE, and RATIONALITY are defective in the sense that the rules for using them are inconsistent. This defect leads those who possess these concepts into paradoxes and absurdities. Indeed, I argue that many of the (...) central problems of contemporary philosophy should be thought of as having their source in philosophical concepts that are defective in this way. If that is right, then we should take a more active role in crafting and sculpting our conceptual repertoire. We need to explore various ways of replacing these defective concepts with ones that will still do the work we need them to do without leading us into contradictions. (shrink)

This essay presents racial literacy and racial dexterity as educational desiderata, especially for white students. Racial literacy is defined as the ability to recognize and interpret racial nuances in real social engagements. Racial dexterity is defined as the ability to engage successfully with diverse racial contexts. After defining racial literacy and racial dexterity, Kevin Harrelson analyzes these skills by contrasting them with racial naivety and racial anxiety. He argues that transitioning from naivety to literacy, and from anxiety to dexterity, (...) requires treating cross-racial interactions as key learning events. (shrink)

Phineas Gage’s story is typically offered as a paradigm example supporting the view that part of what matters for personal identity is a certain magnitude of similarity between earlier and later individuals. Yet, reconsidering a slight variant of Phineas Gage’s story indicates that it is not just magnitude of similarity, but also the direction of change that affects personal identity judgments; in some cases, changes for the worse are more seen as identity-severing than changes for the better of comparable magnitude. (...) Ironically, thinking carefully about Phineas Gage’s story tells against the thesis it is typically taken to support. (shrink)

You can perceive things, in many respects, as they really are. For example, you can correctly see a coin as circular from most angles. Nonetheless, your perception of the world is perspectival. The coin looks different when slanted than when head-on, and there is some respect in which the slanted coin looks similar to a head-on ellipse. Many hold that perception is perspectival because you perceive certain properties that correspond to the “looks” of things. I argue that this view is (...) misguided. I consider the two standard versions of this view. What I call the PLURALIST APPROACH fails to give a unified account of the perspectival character of perception, while what I call the PERSPECTIVAL PROPERTIES APPROACH violates central commitments of contemporary psychology. I propose instead that perception is perspectival because of the way perceptual states are structured from their parts. (shrink)

In their correspondence in 1902 and 1903, after discussing the Russell paradox, Russell and Frege discussed the paradox of propositions considered informally in Appendix B of Russell’s Principles of Mathematics. It seems that the proposition, p, stating the logical product of the class w, namely, the class of all propositions stating the logical product of a class they are not in, is in w if and only if it is not. Frege believed that this paradox was avoided within his philosophy (...) due to his distinction between sense (Sinn) and reference (Bedeutung). However, I show that while the paradox as Russell formulates it is ill-formed with Frege’s extant logical system, if Frege’s system is expanded to contain the commitments of his philosophy of language, an analogue of this paradox is formulable. This and other concerns in Fregean intensional logic are discussed, and it is discovered that Frege’s logical system, even without its naive class theory embodied in its infamous Basic Law V, leads to inconsistencies when the theory of sense and reference is axiomatized therein. (shrink)

Grounding pluralism is the view that there are multiple kinds of grounding. In this essay, I motivate and defend an explanation-theoretic view of grounding pluralism. Specifically, I argue that there are two kinds of grounding: why-grounding—which tells us why things are the case—and how-grounding—which tells us how things are the case.

Most philosophers have largely downplayed any relevance of multiple meanings of the folk concept of truth in the empirical domain. However, confusions about what truth is have surged in political and everyday discourse. In order to resolve these confusions, we argue that we need a more accurate picture of how the term ‘true’ is in fact used. Our experimental studies reveal that the use of ‘true’ shows substantial variance within the empirical domain, indicating that ‘true’ is ambiguous between a correspondence (...) and a coherence reading. We then explore the consequences of these results for the project of re-engineering truth. (shrink)

The personal identity relation is of great interest to philosophers, who often consider fictional scenarios to test what features seem to make persons persist through time. But often real examples of neuroscientific interest also provide important tests of personal identity. One such example is the case of Phineas Gage – or at least the story often told about Phineas Gage. Many cite Gage’s story as example of severed personal identity; Phineas underwent such a tremendous change that Gage “survived as a (...) different man.” I discuss a recent empirical finding about judgments about this hypothetical. It is not just the magnitude of the change that affects identity judgment; it is also the negative direction of the change. I present an experiment suggesting that direction of change also affects neuroethical judgments. I conclude we should consider carefully the way in which improvements and deteriorations affect attributions of personal identity. This is particularly important since a number of the most crucial neuroethical decisions involve varieties of cognitive enhancements or deteriorations. (shrink)

R. M. Hare has argued for and defended a ‘two-level’, view of moral agency. He argues that moral agents ought to rely on the rules of ‘intuitive moral thinking’ for their ‘everyday’ moral judgments. When these rules conflict or when we do not have a rule at hand, we ought to ascend to the act-utilitarian,‘critical’ level of moral thinking. I argue that since the rules at the intuitive level of moral thinking necessarily conflict much more often than Hare supposes, and (...) since we often do not have ready-made rules for our moral judgments, we must necessarily use critical moral thinking very frequently. However, act-utilitarian judgements at this level will sharply conflict with our strongly held ‘intuitive’ moral convictions. I show that Hare's attempt to balance these two aspects of moral judgment requires us to simultaneously adopt two conflicting sets of moral standards, and thus an attempt to inculcate such standards constitutes a ‘schizophrenic’ moral education. Finally, I briefly outline an alternative conception of moral education, based on Aristotelian phronesis. (shrink)

In these articles, I describe Cantor’s power-class theorem, as well as a number of logical and philosophical paradoxes that stem from it, many of which were discovered or considered (implicitly or explicitly) in Bertrand Russell’s work. These include Russell’s paradox of the class of all classes not members of themselves, as well as others involving properties, propositions, descriptive senses, class-intensions, and equivalence classes of coextensional properties. Part I focuses on Cantor’s theorem, its proof, how it can be used to manufacture (...) paradoxes, Frege’s diagnosis of the core difficulty, and several broad categories of strategies for offering solutions to these paradoxes. (shrink)

Batı’da teorik felsefe; Analitik Felsefe (AF), Kıta Felsefesi (KF) ve Felsefe Tarihi (FT) olmak üzere üçe ayrılır. Fakat üçünde de işler yolunda değildir. AF, felsefenin bir bilim olabileceği iddiasından kuşku duyduğu için gerçek dünyayla ilgilenmiyorken başından beri uygun bir teorik yöntem izlemeyen Kıta Felsefesinin uygulanışı, belirli politik ve etik yargılara hizmet edecek şekilde özelleştirilmiştir. FT çalışmalarının gidişatı ise eldeki eserin nesnel değerinden daha çok ilgili filozofun ait olduğu ulus veya kültüre göre bölgesel bir temelde gelişmiştir. Felsefede ilerleme sağlanacaksa bu ancak (...) bahsi geçen tuzaklardan kaçınılarak gerçekleşebilir. (shrink)

Mental capacities for perceiving, remembering, thinking, and planning involve the processing of structured mental representations. A compositional semantics of such representations would explain how the content of any given representation is determined by the contents of its constituents and their mode of combination. While many have argued that semantic theories of mental representations would have broad value for understanding the mind, there have been few attempts to develop such theories in a systematic and empirically constrained way. This paper contributes to (...) that end by developing a semantics for a ‘fragment’ of our mental representational system: the visual system’s representations of the bounding contours of objects. At least three distinct kinds of composition are involved in such representations: ‘concatenation’, ‘feature composition’, and ‘contour composition’. I sketch the constraints on and semantics of each of these. This account has three principal payoffs. First, it models a working framework for compositionally ascribing structure and content to perceptual representations, while highlighting core kinds of evidence that bear on such ascriptions. Second, it shows how a compositional semantics of perception can be compatible with holistic, or Gestalt, phenomena, which are often taken to show that the whole percept is ‘other than the sum of its parts’. Finally, the account illuminates the format of a key type of perceptual representation, bringing out the ways in which contour representations exhibit domain-specific form of the sort that is typical of structured icons such as diagrams and maps, in contrast to typical discursive representations of logic and language. (shrink)

Many have claimed that whenever an investigation might provide evidence for a claim, it might also provide evidence against it. Similarly, many have claimed that your credence should never be on the edge of the range of credences that you think might be rational. Surprisingly, both of these principles imply that you cannot rationally be modest: you cannot be uncertain what the rational opinions are.

Willful ignorance is an important concept in criminal law and jurisprudence, though it has not received much discussion in philosophy. When it is mentioned, however, it is regularly assumed to be a kind of self-deception. In this article I will argue that self-deception and willful ignorance are distinct psychological kinds. First, some examples of willful ignorance are presented and discussed, and an analysis of the phenomenon is developed. Then it is shown that current theories of self-deception give no support to (...) the idea that willful ignorance is a kind of self-deception. Afterwards an independent argument is adduced for excluding willful ignorance from this category. The crucial differences between the two phenomena are explored, as are the reasons why they are so easily conflated. (shrink)